Why the Environment Around an Active Matters
Skincare is often talked about in terms of ingredients. Peptides, niacinamide, retinol, antioxidants. People recognize the names, but very few talk about the environment those ingredients live in.
A good formula is not just a collection of actives. It is a controlled space that protects those actives from breaking down, clashing with each other, or losing their structure long before they ever reach the skin.
This is the part of skincare most consumers never see. It is also the part that determines whether a product works.
DERMA-CODE™ was built on the belief that active ingredients should work together, not compete. That belief is what led to the creation of our Tri-Active System.
Three Molecular Pathways, One Controlled Framework
The Tri-Active System is our stabilization and delivery structure that brings together three high-value ingredient classes inside one unified molecular environment.
The system supports three different biological pathways:
- PDRN (Sodium DNA) supports natural repair and tissue comfort.
- NAD+ (Nicotinamide Adenine Dinucleotide) fuels energy metabolism and helps maintain cellular recovery.
- Peptides communicate with the skin to support firmness, structure, and visible smoothness.
Each of these ingredients is sensitive on their own. When combined without the right environment, they can degrade quickly. The Tri-Active System exists to prevent that from happening.
Why Stabilization Matters More Than the Ingredient List
Two formulas can list the same actives, but behave nothing alike on the skin.
The difference is not the name of the ingredient. It is whether that ingredient is:
• protected from oxidation
• held in the right pH environment
• placed in a compatible carrier
• stabilized enough to remain active
Without these conditions, an ingredient can lose function long before the product is ever opened.
The Tri-Active System was engineered to keep PDRN, NAD+, and peptides stable and active inside the formula. Instead of competing or degrading, they work in a shared network that keeps their structure intact and their purpose clear.
Real performance comes from internal harmony, not ingredient count.
How the Tri-Active System Works Differently
Conventional formulas often rely on emulsifiers and buffers to simply keep ingredients suspended. That approach does not protect sensitive actives from degradation.
The Tri-Active System functions more like a controlled molecular environment. Each ingredient class is kept within its ideal stability range, which prevents conflict between acidic, neutral, and delicate components.
You can think of it as a coordinated system:
• PDRN communicates renewal
• NAD+ delivers usable cellular energy
• Peptides reinforce visible structure
And the surrounding matrix holds everything in place so those signals actually reach the skin the way they are meant to.
The Quiet Science Behind the Visible Results
The Tri-Active System was not created to sound impressive. It was created because PDRN, NAD+, and peptides are extremely challenging to combine in a normal skincare base without losing activity.
Formulating them together requires a controlled approach that helps:
• maintain NAD+ against oxidation
• protect PDRN from pH-related breakdown
• keep peptides structurally intact for proper signaling
This is why our formulas perform without relying on harsh resurfacing agents or heavy film-formers. The system supports the actives so they can work gently and consistently across all skin types.
Why Integrity Matters More Than Trends
Ingredient trends change constantly. What does not change is the biology of the skin and the science required to protect unstable actives.
The Tri-Active System reflects our philosophy: science leads the formula, not marketing.
Innovation is not the number of ingredients listed.
It is how many of those ingredients arrive to the skin in an active state.
Precision, transparency, and trust begin at the molecular level.
Looking Ahead
The Tri-Active System is the foundation of how we formulate, not a one-time concept. As biotechnology continues to evolve, this structure allows us to integrate future actives without compromising stability or performance.
Every DERMA-CODE™ product follows the same principle. Actives only matter when they are active.
And one of those actives, PDRN, reshaped how we think about renewal entirely.
Explore why PDRN represents the next era of gentle, intelligent regeneration in our comparison with retinol.
We earn trust through results, not promises.
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